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The Lophotrochozoa (/ləˌfɒtroʊkoʊˈzoʊə/, "crest/wheel animals") are a major grouping of protostome animals dating back to the early Cambrian. The taxon was discovered based on molecular data. Molecular evidence such as a result of studies of the evolution of small-subunit ribosomal RNA (rRNA) supports the monophyly of the phyla listed in the infobox shown at right.

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